In this respect, we have recently demonstrated that LPA receptor 6 (LPAR6) is directly involved in the control of HCC cell metabolism [155] and that ectopic expression of LPAR6 in HCC cells drives sorafenib resistance by triggering a “metabolic switch”, which increases lactic acid fermentation at the expense of OXPHOS. Here, LPAR6 is linked to hepatocellular carcinoma.