AKT1 and renal cell carcinoma: CD151 has been reported to promote tumor metastasis in breast cancer [141,142], hepatocellular carcinoma [143,144], osteosarcoma [145], RCC [146], and clear cell sarcoma [147] in vitro and/or in vivo, by activating signaling pathways, such as PI3K/AKT, rat sarcoma virus protein (RAS)/rapidly accelerated fibrosarcoma (RAF)/extracellular signal-regulated kinase (ERK), or TGFβ.