TGFB1 and Sepsis: As mentioned earlier, the TNBC-EV-mediated differentiation of monocytes into pro-inflammatory TAMs is stimulated by CSF1 on the surface of TNBC-EVs [109].Other proteins, including milk fat globule-EGF factor 8 (MFGE8), galectin-5, and transforming growth factor beta-1 (TGFβ-1), have been reported to bind to or associate with EV surfaces and have specific roles in apoptotic cell clearance in sepsis, vesicle uptake by macrophages, or recipient cell migration, respectively [182,183,184].