MALAT1 functions by either promoting binding between the ETS proto-oncogene 1 (ETS1) transcription factor and the promoter region of transcription factor CP2 like 1 (TFCP2L) [89], or by sponging miR-26a/26b to activate fucosylation and the phosphoinositide 3-kinase (PI3K)/AKT pathway through fucosyltransferase 4 (FUT4) [88], leading to invasion and metastasis of RCC or CRC cells. This evidence concerns the gene AKT1 and renal cell carcinoma.