NFKB1 and diabetes mellitus: Conversely, members of the miR-146 family are known negative regulators of the inflammatory pathway NF-κB through the suppression of thrombin-induced GPCR-mediated NF-κB activation in human retinal endothelial cells and inhibition of diabetes-induced NF-κB activation and retinal microvascular in diabetic rat models [98,99].