Piperlongumine, a Piper longum-derived alkaloid, causes ROS generation and apoptosis and downregulates c-Myc and its downstream miRNAs, such as miR-27a-3p (miR-27a), miR-20a-5p, and miR-17-5p, in pancreas, lung, and breast cancer cells [154] (Table 3). Here, MYC is linked to breast carcinoma.