CCN1 and liver cancer: For example, solamargine, a Solanum incanum herb-derived natural product, promotes antiproliferative effects, apoptosis, and autophagy in liver cancer cells by downregulating leukemia inhibitory factor (LIF), cysteine-rich angiogenic inducer 61 (CYR61), and AKT and upregulating miR-192-5p (Table 3) [193].