CD274 and cancer: In addition, compared with other tumor treatment methods, such as chemotherapy, targeted therapy, and anti-programmed death (PD)-1/PD-ligand 1 (PD-L1) therapy, OV therapy has the advantage of being able to be customized according to clinical requirements using in vitro gene editing, possessing a better ability to lyse tumors and activate immunity, and meeting the demands of cancer patients who require personalized treatment [8].