ACSS2 and anemia (phenotype): Our analysis showed that Acss2 loss activated upstream regulators Acox1, miR-196a-3p (miRNAs w/seed GGCAACA), and miR-3473h-5p (and other miRNAs w/seed AGGGGCU), leading to alterations in the expression of several genes (listed in Supplementary Table S3A) associated with disease and cellular functions linked to activation of “anemia” and “organ degeneration” (consistency score = 1.897) (Figure 2C).