ACSS2 and connective tissue disorder: Using IPA network analysis, we found the top enriched networks in adipose tissue were “cellular assembly and organization”, “RNA damage and repair”, “RNA post-transcriptional modification” (Network 1, score = 60, focus molecules = 35), and “connective tissue disorders, developmental disorder, hereditary disorder” (Network 2, score = 44, focus molecules = 29) associated with the loss of Acss2 activity (Figure 5E,F respectively).