Other inflammatory molecules are: the soluble receptor IL-2 (sIL-2R), associated with severity [93,94] but with inconclusive results [102]; soluble CD23 (sCD23) [94]; the receptors of soluble Tumor Necrosis Factor (sTNFRI/II) [118]; C-reactive protein (CRP), which is upregulated in AD subjects compared to healthy controls and correlated with disease severity scores [119]; and lactate dehydrogenase (LDH), which is also elevated in AD [99,119] as a potential indicator of disease severity both in children [120], and adults [110]. Here, TNF is linked to Alzheimer disease.