The matrix metalloproteinase 12, MMP-12, was associated with cartilage destruction in arthritis [64], considering that it can degrade different extracellular matrix components, including elastin, collagen IV, fibronectin, laminin, gelatin, vitronectin, entactin, fibrinogen, plasminogen, and chondroitin sulfate [63,65,66]. This evidence concerns the gene FN1 and arthritic joint disease.