For a full evaluation of the role of ATG genes in CRC via the IGF system and as potential therapeutic targets in this cancer, it would also be important to continue research into the role of epigenetic factors that regulate the expression of these genes, and factors such as non-coding RNAs (e.g., miRNAs and lncRNAs) [261,262]. The gene discussed is IGF1; the disease is colorectal carcinoma.