Evidence for the stimulatory effect of IGF-1R on CRC cell proliferation may also be provided by in vitro and in vivo studies using anti-IGF-1R mAbs (alone or in combination with the chemotherapeutic agent oxaliplatin), which inhibited this process, as well as angiogenesis, increasing apoptosis of tumor cells [70]. The gene discussed is IGF1R; the disease is colorectal carcinoma.