The different effects of IGF-1R (picropodophyllin), TLR9 (ODN2088) and autophagy (chloroquine) inhibitors (per se or in combination) on HT29 cells suggested that the IGF-1R-related or non-IGF-1R-related autophagy process, however, also had “Janus-faced” characteristics in terms of its effect on CRC cell proliferation. Here, TLR9 is linked to colorectal carcinoma.