To illustrate the predictive power of the models in explaining chromatin conformations, we consider as a case study a 2.5 Mb wide genomic region (Chr21: 34.6–37.1 Mb, hg38) in a human colon cancer cell line (HCT116) where single-cell microscopy data are available [13] (Figure 2, top panel). This evidence concerns the gene LGR5 and malignant colon neoplasm.