The combined enrichment of the “Insulin secretion,” “Maturity onset diabetes of the young,” and “Type II diabetes mellitus” pathway (Figures S5–S7, * denotes DEGs exclusive to AA-SScL fibroblasts) emphasized a strong perturbation of insulin-related processes in AA-SScL fibroblasts resulting from the DEGs MAPK10, IRS2, HHEX, ADCY1*, SLC2A1, CREB3L1*, CACNA1A*, SOCS2, HES1*, RAPGEF4*, CAMK2B, and KCNMB4*. Here, HES1 is linked to type 2 diabetes mellitus.