Using the iPathwayGuide’s impact analysis, we also identified pathways uniquely enriched in AA-SScL fibroblasts, including insulin signaling and diabetes (“Insulin secretion”; “Maturity onset diabetes of the young”; “Type II diabetes mellitus”), TGFβ signaling, and viral infection (“Viral myocarditis”) (Table 2, underlined). This evidence concerns the gene INS and viral infectious disease.