Amcenestrant (SAR439859) is a nonsteroidal, orally bioavailable, SERD studied in clinical trials (AMEERA) in postmenopausal women with HR+/HER2− advanced breast cancer [83] and in association with CDK4/6 inhibitors, such as palbociclib for previously untreated ER+/HER2− advanced breast cancer [84]. The gene discussed is ESR1; the disease is breast carcinoma.