Up to 44% of sporadic pNENs are known to carry somatic inactivating mutations in the MEN1 gene, too [12,26], but MEN1 syndrome-associated pNENs do not frequently show alterations of the autophagy-associated genes or the PI3K-AKT-mTOR signaling pathway. The gene discussed is AKT1; the disease is multiple endocrine neoplasia type 1.