The chronic target organs damage, which is the most unfavorable effects of hypertension, is mediated by several pathogenic mechanisms associated with the over-activation of pro-inflammatory molecules, growth factors, RAAS agents or reactive oxygen species, and frequently was observed in relation with increased MMPs plasma level (MMP-9, MMP-2, MMP-3 and MMP-1) [85]. The gene discussed is MMP2; the disease is hypertensive disorder.