It regards the MMP-2 polymorphisms -1575 A/G, -1059 A/G, and -790 T/G implicating an increased risk of HF of any etiology and increased risk of cardiac mortality in the Brazilian population, as well those of African as Caucasian origin [72], similarly as -735 C/T polymorphism associated with HF in Czech patients [73]. Here, MMP2 is linked to hydrops fetalis.