CHD4 and nervous system disorder: We found significant enrichment for various neuronal factors such as ADNP, whose mutations underlie a complex neurological disorder (Helsmoortel–Van der Aa syndrome; OMIM#615873), and that interact with TFIIIC in mouse ESCs [19]; CHD4, a chromatin-remodeling enzyme-regulating genome architecture in mouse brain [20], and Polycomb proteins such as RNF2, RYBP, EZH1, EZH2, KDM2B and JARID, all important regulators of neurogenesis and known interactors of TFIIIC in differentiated cells [21,22] (Figure 2D).