Concerning the role of TPH-1 in the development of CHD, it would be interesting to generate transgenic mice models with a monitored secretion of 5-HT, for example, through the use of TPH-1-KO BON1-bearing nude mice, in order to inhibit 5-HT secretion, or otherwise NET-bearing mice with overexpression of TPH-1 to increase 5-HT secretion and generate a CHD model. This evidence concerns the gene TPH1 and coronary artery disorder.