The first test case regarded protein kinase 1 δ, a serine-threonine kinase belonging to the family of CK1 kinases [37] that is involved in several neurodegenerative illnesses like Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis [38] due to its pleiotropic nature [39]. This evidence concerns the gene MARK2 and early-onset autosomal dominant Alzheimer disease.