EWSR1 and Ewing sarcoma: In Ewing sarcoma, for instance, transcription factor MEIS1 was identified as a super-enhancer-associated gene, which co-operates with EWS-FLI1 oncoprotein to directly co-bind super-enhancer regions of APCDD1, and activates the transcription of APCDD1, thereby inhibiting cell apoptosis [29].