The C-X-C chemokine ligand 13 (CXCL13) and C-X-C chemokine receptor type 5 (CXCR5) signaling axis, for instance, play an essential role in B cell recruitment and tertiary lymphoid structure formation, which is transcriptionally activated by a common transcription factor RelA, a subunit of the NF-κB family in breast tumors [5]. Here, CXCR5 is linked to breast neoplasm.