TGFB1 and esophageal squamous cell carcinoma: The transforming growth factor-β (TGF-β) signaling pathway is one of the most important signaling pathways necessary for development and health in mammals, and many of its members have been demonstrated to be the targets of miR-130a-3p, such as TGF-β1 (the main ligand) [6], TGFBR1 (the type I receptor) [7], TGFBR2 (the type II receptor) [8], SMAD4 (only co-SMAD) in esophageal squamous cell carcinoma [9].