In addition, focusing on the SARS-CoV-2 signalling pathway, it has been noted that the proteins upregulated in SEVEREs refer to positively regulated virus-mediated pathways (such as SAA1/2, CRP, HP, LRG1), while proteins overexpressed in MILDs (GSN and HRG) are connected to processes that are expected to be negatively regulated in COVID-19, suggesting a potentially protective role of these molecules for serious outcomes. This evidence concerns the gene LRG1 and COVID-19.