Makund et al. demonstrated that a significant common program of transcriptional dysregulation of immunoglobulin genes, including IGLC2 and IGHA1/IGHM/IGKC/IGLC3, exists across both the myeloid and lymphoid milieu of COVID-19 patients, even if they do not differ across severities [30]. The gene discussed is IGLC2; the disease is COVID-19.