TNFSF10 and neoplasm: For example, MSCs were genetically modified to express gene products, including IFNs, CX3CL1, FLT3, tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL), HGF, and GDEPT, with direct anti-tumor activity in various cancers, such as melanoma, glioma, and breast, lung, and prostate cancers [74,80,84].