As of 2021, 395 genes (CPO: 367 genes; anterior cleft: 16 genes; posterior/soft palate cleft: 15 genes; submucous cleft: 37 genes; and CLP: 44 genes) were reported as genes related to cleft palate in mice and 131 genes in humans [78,79] (the updated list of genes is available at CleftGeneDB; Table 1). Here, CPO is linked to cleft palate.