SLC5A2 and hydrops fetalis: In a study of targeted metabolomics in a randomized controlled trial (RCT) of SGLT-2 inhibitors (SGLT-2i) in HFrEF (Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With HF With Reduced Ejection Fraction—DEFINE-HF), effects were observed of dapagliflozin on principal metabolic pathways, backing a role for modified ketone and fatty acid biology with SGLT-2i in patients with HFrEF [78].