RRP15 and infectious otitis media: In the future study, RRP15 knockout mice will be further used to study the roles of RRP15 in CC tumorigenesis and AOM/DSS-induced CAC mice; (3) The underlying mechanisms of RRP15 in regulating CC cell proliferation and invasion also require further investigation; (4) As is known to all, CC is prone to liver metastasis, thus whether RRP15 participates in regulating liver metastasis should be clarified.