Notably, the limitations of this study are as follows: (1) we found that HCT15 cells had poor tumorigenicity while HCT116 cells had good tumorigenicity in subcutaneous transplant tumor; (2) Our study also showed higher RRP15 expressions in AOM/DSS-induced CAC mice, its functions and regulatory mechanisms in AOM/DSS-induced CAC mice urge further clarification. The gene discussed is RRP15; the disease is neoplasm.