RHOA and autosomal dominant polycystic kidney disease: In autosomal dominant polycystic kidney disease (ADPKD), Streets et al. found that PKD1 defects decreased the expression of centrosomal ARHGAP35, which is attributed to persistent RhoA activation and its downstream signals and associated cellular biological changes, such as actin cytoskeleton disorganization, ciliogenesis disturbance, and cell morphology changes [16].