NOTCH1 and glioblastoma: In GBM cells, elevated levels of Notch1 and 2 receptors stimulate the proliferation and migration of glioma cells by activating the kinases of the AKT-mTOR pathway [121] and also affects the regulation of EGFR receptor expression by the p53 protein, which reduces signal transmission and consequently intensifies the metastasis of cancer cells [30].