Interestingly, CDK6, another target of the hsa-miR-29a miRNA, was found to mediate the recruitment of the transcription factors c-Jun and Sp1 to the MMP2 promoter that positively enriched the angiogenic and fibrotic tumor microenvironment, as widely observed in TNBC (ER−) patient tissues [51]. Here, SP1 is linked to neoplasm.