Liposomal nanoparticles with IL-2 and TGF β can mediate macrophage and NK cell homing and infiltration in the tumor site, and nanocomposite containing IFNγ or IL-2 can facilitate the conversion of immunosuppressive TME to more immunoresponsive environment enhancing NK tumor recognition and killing [171,172]. Here, IFNG is linked to neoplasm.