In this study, we reported that VPS26A mRNA and protein expression were upregulated in PAAD tissues as compared to normal pancreatic tissues in the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Human Protein Atlas (HPA) databases and our independent PAAD cohort. This evidence concerns the gene VPS26A and neoplasm.