We subsequently found that VPS26A increased the phosphorylation of EGFR and ERK, and accordingly regulated the downstream molecules of EGFR/ERK signaling, such as c-Myc (for growth regulation) and Snail1, ZEB1, CDH1, CDH2 and Vimentin (for the regulation of migration and invasion) in PAAD cell lines (Figure 8D,E). This evidence concerns the gene VPS26A and pancreatic adenocarcinoma.