In this study, we reported that VPS26A mRNA and protein expression were upregulated in PAAD tissues as compared to normal pancreatic tissues in the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Human Protein Atlas (HPA) databases and our independent PAAD cohort. The gene discussed is VPS26A; the disease is cancer.