We subsequently found that VPS26A increased the phosphorylation of EGFR and ERK, and accordingly regulated the downstream molecules of EGFR/ERK signaling, such as c-Myc (for growth regulation) and Snail1, ZEB1, CDH1, CDH2 and Vimentin (for the regulation of migration and invasion) in PAAD cell lines (Figure 8D,E). The gene discussed is CDH2; the disease is pancreatic adenocarcinoma.