The results showed that most of the genes positively related to VPS26A, such as ACTR3, RAB6A, HK1 and VCL, might be risk factors for PAAD, while the genes negatively related to VPS26A, including DPH1, UNK and TOM1L2, might be protective factors for PAAD. Here, VCL is linked to pancreatic adenocarcinoma.