ENAM and amelogenesis imperfecta: Mutations in the genes encoding the major structural proteins in enamel—namely amelogenin (Amel), ameloblastin (Ambn), enamelin (Enam), and amelotin (Amtn)—are associated with amelogenesis imperfecta (AI) [8,9,10,11], a hereditary disorder characterized by hypoplastic (thin) and/or hypomineralized (weak) enamel [12].