The results clearly suggest that long-term HFD feeding promotes the expression of genes associated with AD, including Ache, App, Apba3, Apbb2, Aplp1, Aplp2, Apoe, CdK5, Clu, Ctls, GSK3α, Hsd17b10, Mapt, Psen1, Prkca,Prkcb and genes linked to inflammation such as Mpo and Il1α [56,57]. This evidence concerns the gene APLP2 and Alzheimer disease.