With the deeper understanding of pathophysiological function and mechanism of RORα in the cardiovascular system and not just in circadian rhythm regulation, several independent studies have confirmed that RORα has a potential protective effect against a variety of cardiovascular diseases as a negative factor, which offers novel therapeutic approaches for cardiovascular diseases including atherosclerosis, hypoxia, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, hypertension, and myocardial hypertrophy. Here, RORA is linked to hypertensive disorder.