It is worth mentioning that another group proposed spleen tyrosine kinase/mitochondrial complex I/sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) axis activation as a novel pathway contributing to DCM, which was able to be blocked by RORα activation via alleviating caspase-9-involved mitochondrial apoptosis and caspase-12-related ER apoptosis-mediated cardiomyocyte damage [47]. The gene discussed is RORA; the disease is familial dilated cardiomyopathy.