The coumarin-loaded BBN-conjugated nanocarriers showed an improved C6 cell uptake over PEG-PCL-Tat(49–57) (17 vs. 10%), and the researchers established that their absorption into the tumor might occur through macropinocytosis by Tat(49–57) and clathrin-mediated endocytosis by BBN, making bombesin an important modulator of the intratumoral uptake. This evidence concerns the gene TAT and neoplasm.