Specifically, several ALS-linked TDP-43 mutations (including A315T, M337V, and G376D) cause TDP-43 mislocalization [109,110,111], whereas other ALS-linked mutations (such as Q331K, M337V, Q343R, N345K, R361S, and N390D) facilitate the aggregation of TDP-43 [112]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.