CD274 and hepatocellular carcinoma: A recent study by Hu et al., exploring the association between immune microenvironment, TMB, mutation signature, and driver-gene mutations in Chinese HCC patients, observed that high values of TMB (>10 mutations/megabase) are associated with increased PD-L1 expression, as well as increased numbers of CD3+ T-cells, CD68+ TAMs, and CD66b+ TANs.