This study observed that 10 genes are frequently mutated in HCC, i.e., TP53, TTN, CTNNB1, MUC16, ALB, PCLO, MUC, APOB, RYR2, and ABCA, and 4 of them (CECR7, GABRA3, IL7R, and TRIM16L) are correlated to TMB and prompt antitumor immune infiltration. This evidence concerns the gene MUC16 and hepatocellular carcinoma.