HTRA1 and age-related macular degeneration: Genome-wide association studies (GWAS) have successfully identified loci associated with genetic variants implicated with AMD risk and traits, with over 60 genetic variants being associated with AMD [2,3,4,5,6], including variants within the APOE, CFH, ARMS2/HTRA1 and TMEM97/VTN loci that confer risk of developing AMD.