Correspondingly, the levels of serum alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (T-bil), and hydroxyproline were also significantly higher in model mice than in the corresponding controls (Figure 5C), while neddylation inhibition by MLN4924 remarkably alleviates CCl4-induced liver fibrosis (Figure 5B,C). Here, GPT is linked to Hepatic fibrosis.