PPARGC1A and atrial fibrillation: In the study by Shao and co-workers, the T2DM animal group exhibited higher incidence of AF; this event was correlated to a significant reduction in protein expression of PGC-1α, NRF-1 and TFAM, as well as the concomitant downregulation of DRP1, MFN1 and OPA1 [95].