There was a significant decrease in the negative M values for the two CpG probes for CYSLTR1 in colon tumors (cg00813999 and cd26848126, Figure 2A,B) and rectal tumors (cg16886259 and cg16299590, Figure 2C,D) compared with matched normal samples. The gene discussed is CYSLTR1; the disease is colonic neoplasm.