However, a significant decrease in positive M-values for the CpG probe cg16886259 (Figure 2E,G) and an increase in positive M-values for the CpG probe cg16299590 (Figure 2F,H) for CYSLTR2 were observed in the colon and rectal tumors compared with matched normal samples. This evidence concerns the gene CYSLTR2 and rectal neoplasm.