Among all the clinicopathological factors, a history of colon polyps was significantly correlated with CYSLTR1 gene expression in CRC patients, but the sample type (metastasis, normal and primary tumor) was significantly correlated with CYSLTR1 and CYSLTR2 gene expression in colon and rectal cancer patients (Supplementary Figure S4). This evidence concerns the gene CYSLTR2 and colon inflammatory polyp.