Our findings of a reduced content of proteins involved in fatty acid oxidation and increased glycolysis in CBL-depleted cells is in agreement with findings in the muscle of STZ-induced diabetic mice [7].Triglyceride levels in CBL/CAP-deficient cells were, however, not different than control cells, in agreement with findings in mice lacking insulin receptor (MIRKO) or following streptozotocin-induced diabetes [3]. Here, SORBS1 is linked to diabetes mellitus.