The CRP, an inflammatory biomarker that is present in most cardiac pathologies, and whose production may be triggered by metabolic hallmarks of diabetes—high glucose, adipokines, lipoproteins and free fatty acids—plays a role in the development and progression of most CVD, with immunomodulatory roles in the humoral innate immune and complement responses, as well as in vascular function [201]. This evidence concerns the gene CRP and diabetes mellitus.