For instance, night eating syndrome is associated with obesity [218], and in overweight female night shift workers, compared to overweight day shift workers (with no difference in BMI), the post-meal suppression of ghrelin production was blunted, resulting in elevated waist circumference, greater energy intake, impaired sleep, insulin insensitivity, increased triglycerides and increased C-reactive protein (CRP) [219]. The gene discussed is GHRL; the disease is obesity due to melanocortin 4 receptor deficiency.