Ghrelin protected against obesity-induced cardiomyocytes apoptosis and the pro-inflammatory environment caused by the high-fat diet or palmitic acid by the regulation of lncRNA H19/miR-29/IGF-1 [210] and Homeobox transcript antisense RNA (HOTAIR)/miR-196b/IGF-1 axis [56], novel signaling cascades involved in metabolic cardiac injury. This evidence concerns the gene IGF1 and obesity disorder.