On the contrary, in an animal model of myocardial infarction, selective GIPR inactivation reduced the ventricular injury, improved survival, and increased myocardial triacylglycerol (TAG) content by decreasing hormone-sensitive lipase (HSL) phosphorylation via PKG/ERK pathway, suggesting an adaptive role for GIPR signaling in ischemic conditions [171]. The gene discussed is LIPE; the disease is myocardial infarction.