SLC1A3 and acute lymphoblastic leukemia: Several amino acids, including Gln, can serve as signalling molecules to activate mTORC1 [37], which, in turn, can control mitochondrial function (the TCA), nutrient uptake and glutaminolysis [38] (by upregulation of the glutamate transporter EAAT1 in T-ALL [39]), while also ultimately enhancing cell growth and survival [40].