In our previous studies, we demonstrated the robust recovery of the HFS-LTP by PLD1 inhibition in the hippocampal Schaffer collateral modeled using AD pathology-dependent amyloidogenic proteins (AβO or TauO) acutely in wildtype mice [15] and chronically in 6-month-old 3xTg-AD mouse models [42]. The gene discussed is PLD1; the disease is Alzheimer disease.