PLD1 and Mental deterioration: Since PLD1 levels were elevated in the astrocytic and mitochondrial compartments in the previously reported study, our future studies will explore mechanisms in which PLD1 has been implicated and plays an important role in the progression of neurodegenerative states including autophagy [29,94,95,96], neuroinflammation [35,64,97,98,99,100,101,102], reactive oxygen species [103,104,105,106] and infection [35,107,108,109] and how these contribute to the synaptic dysfunction leading to cognitive decline in our studies.