Since Aβ and tau accumulation continue increasing in 3xTg-AD with age, and our data suggesting crude synaptosomal PLD1 expression also increases from 6 months to 18 months [15], we asked whether PLD1 inhibition was effective at 12 months, when the levels of tau are significantly higher, than at 6 months. Here, PLD1 is linked to Alzheimer disease.