MMP9 and cancer: The results demonstrated that the protein levels of PI3K, p-Akt, p-m-TOR, and MMP-9 were notably suppressed in T2 and more notably suppressed in T3, whereas the protein level of P-TEN, an index of anti-cancer proliferation, revealed an inversed manner of the PI3K/p-Akt/p-m-TOR biomarkers among the groups (Supplementary Figure S2), suggesting the results supported our hypothesis.