PRNP and breast cancer: The analytical results illustrated that (1) the cellular expression of PrPC in BC tissue was significantly increased when compared with the normal bladder specimen; (2) when we looked at the correlation between BC stage (i.e., TNM staging system) and the expression of PrPC, we found that the cellular expression of PrPC was significantly upregulated in patients with stage II BC when compared to those with Stage I BC, suggesting that our hypothesis was reasonable.