Nho et al. [163] have correlated aberrant liver function (represented by the activities of serum-based liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) in 1,500 AD patients to more significant brain atrophy detected by MRI, disrupted brain glucose metabolism measured by 18F-FDG PET, and increased Aβ accumulation showed by 18F-florbetapir PET. This evidence concerns the gene GPT and Brain atrophy.