LDLR and familial hypercholesterolemia: According to the obtained results, we can conclude that the p.(Arg160Gln) PCSK9 variant is a LOF PCSK9 variant whose loss of activity is caused by a displacement of the PCSK9 P’ helix, which reduces the stability of the LDLr-PCSK9 complex, thus not causative of familial hypercholesterolemia.