After building some regression models among them, we further identified that six genes (TPX2, KIF4A, UBE2S, RAN, BCAR3, YWHAG) are associated with significantly shorter OS whereas eight genes (RAB11A, GPLD1, EPAS1, GOT2, KDR, ATF3, KLKB1, SLC22A1) correlated with longer OS in HCC patients. This evidence concerns the gene KLKB1 and hepatocellular carcinoma.