Similarly, supplementation of curcumin capsule (1500 mg/d, 300 mg/d) in patients with T2DM significantly reduced TNF-α, IL-6, hs-CRP and leptin levels, while it significantly increased adiponectin and SOD levels, thereby improving oxidative stress and inflammatory states [32,33,40]. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.