CD8A and esophageal squamous cell carcinoma: Similarly, machine learning applied to GSE20347, GSE38129, GSE75241, and TGCA datasets has identified the diagnostic biomarkers GPX3, MMP1, and MMP12 associated with immune cell (CD8+ T cells, M0 and M2 macrophages, and dendritic cells) infiltration in ESCC [120].