Studies of α-SMA and ACTA2 mutations demonstrated that it caused various vasculopathies such as the early onset of coronary artery disease, ischemic strokes, and familial thoracic aortic aneurysms and dissections [28]. The gene discussed is ACTA1; the disease is marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections.